Genetic Testing for Hereditary Breast and/or Ovarian Cancer Syndrome (BRCA1 or BRCA2)

Patient Selection Criteria Coverage eligibility for genetic testing for BRCA1 and BRCA2 mutations in cancer-affected individuals will be considered when ANY of the following criteria are met:  Individual from a family with a known BRCA1/BRCA2 mutation  Personal history of breast cancer and ≥1 of the following: o Diagnosed age ≤45 years o 2 primary breast cancers when 1st breast cancer diagnosis occurred age ≤50 years o Diagnosed age ≤50 years AND:  ≥1 1st-, 2nd-, or 3rd-degree relative a with breast cancer at any age, or  Unknown or limited family history o Diagnosed age ≤60 years with a triple negative (ER–, PR–, HER2–) breast cancer o Diagnosed any age AND ≥1 1st-, 2nd-, or 3rd-degree relative with breast cancer diagnosed ≤50 years o Diagnosed any age AND ≥2 1st-, 2nd-, or 3rd-degree relatives with breast cancer at any age o Diagnosed any age AND ≥1 1st-, 2nd-, or 3rd-degree relative with epithelial ovarian/fallopian tube/primary peritoneal CA o Diagnosed any age AND ≥2 1st-, 2nd-, or 3rd-degree relatives with pancreatic cancer or b prostate cancer at any age o 1st-, 2nd-, or 3rd-degree male relative with breast cancer o Ethnicity associated with deleterious founder mutations, eg, Ashkenazi Jewish descent c